Platform Biologist, CRISPR Screening
Implement comprehensive functional genomic sequences orchestrating deep pooled CRISPR iterations validating critical target hypotheses system-wide.
About the role
As a Platform Biologist, you will manage comprehensive pooled CRISPR screening campaigns. The role encompasses executing lentiviral operations, maintaining strict quality control metrics, and producing high-fidelity genomic samples utilized across functional discovery frameworks.
- Team: Functional genomics platform of 6 across screening, assay biology, and follow-up validation
- Stage: Series A platform company expanding discovery collaborations and internal programmes
- Reporting line: Director, Functional Genomics
- Rhythm: Lab-based role in Cambridge with limited remote flexibility
Responsibilities
- Utilize extensive operational workflows spanning targeted cell expansion arrays, precise lentiviral implementations, rigorous selection criteria, and seamless multi-channel NGS integrations comprehensively.
- Audit overarching system consistency mapping specific replication consistencies, MOI integrity, and isolated cell health variables perpetually resolving drift factors swiftly.
- Draft absolute procedural tracking matrices monitoring operational variations confirming consistent operational baseline reliability seamlessly sequentially.
- Construct dense programmatic genomic models tracking precise cell pathways coordinating intimately with localized analytical computation units entirely.
Requirements
- MS or corresponding extensive laboratory experience navigating molecular biology structures, focusing distinctly upon highly demanding platform-driven array implementations inherently.
- Sustained corporate exposure (3+ years) operating explicit functional methodologies spanning pooled integrations, continuous CRISPR structures, and advanced viral array manipulations strictly.
- Stringent tissue culture implementation spanning rigid BSL-2 viral execution sequences, massive replication processing, and explicit representation requirements seamlessly.
- Deep empirical metrics understanding encompassing replication tracking, precise MOI adjustments, target controls mapping, and definitive early-stage campaign curtailment logic reliably.
- Exceptional capability structuring specific multi-layered execution sequencing mapping downstream tracking procedures successfully natively.
- Profound logic skills separating genuine bioanalytical outcomes distinguishing underlying biological artifacts rapidly explicitly.
Preferred qualifications
- Clear experience executing comprehensive FACS/Flow sorting logic adjacent strictly to pooled biological applications frequently.
- Exceptional computational scripting exposure generating fundamental review procedures integrating MAGeCK, targeted CRISPResso tracking capabilities natively.
Technical stack
- CRISPR processing methodologies
- lentiviral processing integrations
- system replication logic arrays
- complex genomic DNA sequences
- flow tracking assessments
- NGS alignment paradigms
What we offer
- Base salary: $132k - $158k
- Equity / upside: Series A equity plus annual bonus.
- Benefits: Medical, dental, vision, 401(k), commuter support, and relocation on a case-by-case basis.
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